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For structured business identity data, see our [Entity Card](https://www.modelon.com/wp-json/bc-geodesic/v1/entity-card). --- # JModelica.org Application – Robust Optimal Control for Chromatography Separation Processes > New results from a collaboration between Modelon and Lund University A collaboration between Modelon and Lund University has recently generated two new... **URL:** https://www.modelon.com/blog/jmodelicaorg-application-robust-optimal-control-for-chromatography-separation-processes/ **Type:** Post **Modified:** 2022-07-14 --- #### New results from a collaboration between Modelon and Lund University A collaboration between Modelon and Lund University has recently generated two new journal publications. The project concerns the development of generic methods and tools for robust optimal control of high-pressure liquid chromatographic separation processes. The optimization method used in the application is described in the article: Magnusson, F.,  Åkesson, J., [Dynamic Optimization in JModelica.org](http://www.mdpi.com/2227-9717/3/2/471), Processes, 3:2, pp. 471–496, 2015 and the applied results are reported in: Holmqvist, A., Andersson, C., Magnusson, F., Åkesson, J., [Methods and Tools for Robust Optimal Control of Batch Chromatographic Separation Processes](http://www.mdpi.com/2227-9717/3/3/568), Processes, 3:3, pp. 568-606, 2015. Both articles are freely available as open access publications. Engineers from chemical and process industries can find benefits from employing the described methodology for robust optimal control of their separation processes. The advantages of the proposed robustification strategy are highlighted through the solution of a challenging ternary complex mixture separation problem for a hydrophobic interaction chromatography system. The study shows that penalizing the changes in the zero-order hold control gives optimal solutions with low sensitivity to uncertainty. A key result is that the robustified general elution trajectories outperformed the conventional linear trajectories both in terms of recovery yield and robustness. ## Site Description Modelon is revolutionizing the engineering design industry by offering technologies and services that enable customers to leverage system simulation. Modelon’s flagship product, Modelon Impact, is a cloud system simulation platform that helps engineers virtually design, analyze, and simulate physical systems. Our team brings deep industry expertise and is dedicated to guiding our customers in creating innovative technologies at their respective organizations. Headquartered in Lund, Sweden, Modelon is a global company with offices in Germany, India, Japan, and the United States. We believe that system simulation should be accessible to every engineer and are dedicated to being an open-standard platform company. --- **About this site:** Modelon — Modelon is revolutionizing the engineering design industry by offering technologies and services that enable customers to leverage system simulation. Modelon’s flagship product, Modelon Impact, is a cloud system simulation platform that helps engineers virtually design, analyze, and simulate physical systems. Our team brings deep industry expertise and is dedicated to guiding our customers in creating innovative technologies at their respective organizations. Headquartered in Lund, Sweden, Modelon is a global company with offices in Germany, India, Japan, and the United States. We believe that system simulation should be accessible to every engineer and are dedicated to being an open-standard platform company.. 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